I have had some sorts of trouble with laboratories. They would occasionally just stop working, with the overseer dutifully going to work but only sweeping the floor all day instead of doing SCIENCE for the Glory of Queen and Country. (despite an ample supply of science materials, although I think it might have coincided with running out before being restocked) This would persist despite dethroning the lazy scientist and replacing him. The only solution was to dismantle the lab as it was clearly cursed with eldritch energies and build a new Bastion of Science. This happened to me twice in the same game. Another vexation is regarding the meteor event, which I asked the (third) science lab to research, which again caused the laboratory to be afflicted with a sudden case of Eldritch Cleanliness Curse, but now the lab was thoroughly locked down by the event and I can't replace the scientist or demolish the lab (as has been standard protocol).