After the first patch, Dredmor didn't even load up at all (nothing happened after I clicked "start game" in the launcher). However, I only needed to right click Dungeons of Dredmor in my games library --> Properties --> Local Files --> Verify Integrity of Game Cache. A file was invalid, Steam fixed it, and now I can play again. Just thought that'd be helpful to post here. P.S. I love the game!
