If you don't mind a mod skill in the mix, I've had hella fun with this: Killer Vegan Ninjitsu Vampirism Thrown Weapons Alchemy Smithing Tourist OR Paranormal Investigator Seems odd, but it works surprisingly well. There's a LOT of synergies: Keeping Full HP: Vegan gives HP and HP regen, which helps Vampirism leech more with every kill/corpse drain. Alchemy gives oodles of Healing Potions (don't bother saving your iron for Smithing), and Mana Potions to power your Ninjitsu spells. Smithing gives you 2 Iron Ingots out of each Iron Ore (which means 4 rust, which means 4 Healing Potions.) Tourist is one more point of HP regen, and Vampirism scales off of it fast, so every point really counts. Avoiding Melee: Vegan gives pets and Blinding Flash procs, which make it easier to stay out of melee. Throwing gives Monster Toss, which also makes staying out of melee easier. Ninjitsu gives you invisibility-on-dodge and a get-out-of-melee-free spell (Substitution Jutsu) and a stun-on-crit proc. Killing Stuff: Vegan gives Righteous Damage, which applies to thrown weapons. Ninjitsu gives you unlimited throwing ammo. Smithing gives you Throwing Stars out of steel igots and NZappa Zapps out of Crude Iron Axes (so save them all!) Alchemy gives you the almighty Noxious Brimstone Flask as well as a small variety of other AoE Throws. Ninjitsu has wild and crazy throwing procs with Kuji Kiri Throwing procs Fleshbore and Crushed Bones, making your thrown attacks nastier. Other: Tourist gives your Vampire the ability to eat anything, which is nice, and the Get Out Of Trouble Free card, which you can totally cheat with by spreading your various Throwing Daggers out across your inventory, making it quite likely that you'll drop one of those instead of anything important. Paranormal Investigator, on the other hand, has Xenochemistry which works well with Alchemy, and also has Alien Autopsy, which works well with the multiple crafting skills to make sure you'll have plenty of high-end hidden recipes by the time you can use them.